CVE-2026-31967

HTSlib CRAM reader has out-of-bounds read due to improper validation of input

Published Mar 18, 2026 CVSS 4.0 · 6.9 Medium EPSS < 1% KEV · Not listed
Description
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. In the `cram_decode_slice()` function called while reading CRAM records, the value of the mate reference id field was not validated. Later use of this value, for example when converting the data to SAM format, could result in the out of bounds array reads when looking up the corresponding reference name. If the array value obtained also happened to be a valid pointer, it would be interpreted as a string and an attempt would be made to write the data as part of the SAM record. This bug may allow information about program state to be leaked. It may also cause a program crash through an attempt to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Remediation

No solution or workaround provided in the CVE record

Tracking

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Advisories

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History
Type Values Removed Values Added
First Time appeared Htslib
Htslib htslib
CPEs cpe:2.3:a:htslib:htslib:*:*:*:*:*:*:*:*
cpe:2.3:a:htslib:htslib:1.23:*:*:*:*:*:*:*
Vendors & Products Htslib
Htslib htslib
Metrics cvssV3_1

{'score': 9.1, 'vector': 'CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:H/I:N/A:H'}

Type Values Removed Values Added
First Time appeared Samtools
Samtools htslib
Vendors & Products Samtools
Samtools htslib
Type Values Removed Values Added
Metrics ssvc

{'options': {'Automatable': 'yes', 'Exploitation': 'none', 'Technical Impact': 'partial'}, 'version': '2.0.3'}

Type Values Removed Values Added
Description HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. In the `cram_decode_slice()` function called while reading CRAM records, the value of the mate reference id field was not validated. Later use of this value, for example when converting the data to SAM format, could result in the out of bounds array reads when looking up the corresponding reference name. If the array value obtained also happened to be a valid pointer, it would be interpreted as a string and an attempt would be made to write the data as part of the SAM record. This bug may allow information about program state to be leaked. It may also cause a program crash through an attempt to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
Title HTSlib CRAM reader has out-of-bounds read due to improper validation of input
Weaknesses CWE-125
CWE-129
References
Metrics cvssV4_0

{'score': 6.9, 'vector': 'CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:L/VI:N/VA:L/SC:N/SI:N/SA:N'}

Weaknesses

Sources

Status
PUBLISHED
Assigner
GitHub_M
Published
Updated
Mar 18, 2026, 7:58 PM
Reserved
Mar 10, 2026, 3:40 PM
Status
Analyzed
Published
Mar 18, 2026, 8:16 PM
Modified
Jun 17, 2026, 10:34 AM