CVE-2026-31965

HTSlib CRAM reader has out-of-bounds reads due to improper validation of input

Published Mar 18, 2026 CVSS 4.0 · 6.9 Medium EPSS < 1% KEV · Not listed
Description
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. In the `cram_decode_slice()` function called while reading CRAM records, validation of the reference id field occurred too late, allowing two out of bounds reads to occur before the invalid data was detected. The bug does allow two values to be leaked to the caller, however as the function reports an error it may be difficult to exploit them. It is also possible that the program will crash due to trying to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Remediation

No solution or workaround provided in the CVE record

Tracking

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Advisories

No advisories available
History
Type Values Removed Values Added
Metrics ssvc

{'options': {'Automatable': 'yes', 'Exploitation': 'none', 'Technical Impact': 'partial'}, 'version': '2.0.3'}

Type Values Removed Values Added
First Time appeared Htslib
Htslib htslib
CPEs cpe:2.3:a:htslib:htslib:*:*:*:*:*:*:*:*
cpe:2.3:a:htslib:htslib:1.23:*:*:*:*:*:*:*
Vendors & Products Htslib
Htslib htslib
Metrics cvssV3_1

{'score': 5.6, 'vector': 'CVSS:3.1/AV:L/AC:L/PR:L/UI:R/S:U/C:L/I:N/A:H'}

cvssV3_1

{'score': 8.2, 'vector': 'CVSS:3.1/AV:N/AC:L/PR:N/UI:N/S:U/C:L/I:N/A:H'}

Type Values Removed Values Added
First Time appeared Samtools
Samtools htslib
Vendors & Products Samtools
Samtools htslib
Type Values Removed Values Added
References
Metrics threat_severity

None

cvssV3_1

{'score': 5.6, 'vector': 'CVSS:3.1/AV:L/AC:L/PR:L/UI:R/S:U/C:L/I:N/A:H'}

threat_severity

Moderate

Type Values Removed Values Added
Description HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. In the `cram_decode_slice()` function called while reading CRAM records, validation of the reference id field occurred too late, allowing two out of bounds reads to occur before the invalid data was detected. The bug does allow two values to be leaked to the caller, however as the function reports an error it may be difficult to exploit them. It is also possible that the program will crash due to trying to access invalid memory. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
Title HTSlib CRAM reader has out-of-bounds reads due to improper validation of input
Weaknesses CWE-125
CWE-129
References
Metrics cvssV4_0

{'score': 6.9, 'vector': 'CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:L/VI:N/VA:L/SC:N/SI:N/SA:N'}

Weaknesses

Sources

Status
PUBLISHED
Assigner
GitHub_M
Published
Updated
Mar 19, 2026, 2:52 PM
Reserved
Mar 10, 2026, 3:40 PM
Status
Analyzed
Published
Mar 18, 2026, 7:16 PM
Modified
Jun 17, 2026, 10:34 AM
Severity
Moderate
Public date
Mar 18, 2026, 6:50 PM