CVE-2026-31963

HTSlib CRAM reader has heap buffer overflow due to improper validation of input

Published Mar 18, 2026 CVSS 4.0 · 8.8 High EPSS < 1% KEV · Not listed
Description
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it stores a location in an external reference sequence along with a list of differences to the reference at that location as a sequence of "features". When decoding these features, an out-by-one error in a test for CRAM features that appear beyond the extent of the CRAM record sequence could result in an invalid write of one attacker-controlled byte beyond the end of a heap buffer. Exploiting this bug causes a heap buffer overflow. If a user opens a file crafted to exploit this issue, it could lead to the program crashing, or overwriting of data and heap structures in ways not expected by the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Remediation

No solution or workaround provided in the CVE record

Tracking

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Advisories

No advisories available
History
Type Values Removed Values Added
First Time appeared Htslib
Htslib htslib
CPEs cpe:2.3:a:htslib:htslib:*:*:*:*:*:*:*:*
cpe:2.3:a:htslib:htslib:1.23:*:*:*:*:*:*:*
Vendors & Products Htslib
Htslib htslib
Metrics cvssV3_1

{'score': 7.3, 'vector': 'CVSS:3.1/AV:L/AC:L/PR:L/UI:R/S:U/C:H/I:H/A:H'}

cvssV3_1

{'score': 8.1, 'vector': 'CVSS:3.1/AV:N/AC:L/PR:N/UI:R/S:U/C:N/I:H/A:H'}

Type Values Removed Values Added
First Time appeared Samtools
Samtools htslib
Vendors & Products Samtools
Samtools htslib
Type Values Removed Values Added
Weaknesses CWE-193
References
Metrics threat_severity

None

cvssV3_1

{'score': 7.3, 'vector': 'CVSS:3.1/AV:L/AC:L/PR:L/UI:R/S:U/C:H/I:H/A:H'}

threat_severity

Important

Type Values Removed Values Added
Metrics ssvc

{'options': {'Automatable': 'yes', 'Exploitation': 'none', 'Technical Impact': 'partial'}, 'version': '2.0.3'}

Type Values Removed Values Added
Description HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data. As one method of removing redundant data, CRAM uses reference-based compression so that instead of storing the full sequence for each alignment record it stores a location in an external reference sequence along with a list of differences to the reference at that location as a sequence of "features". When decoding these features, an out-by-one error in a test for CRAM features that appear beyond the extent of the CRAM record sequence could result in an invalid write of one attacker-controlled byte beyond the end of a heap buffer. Exploiting this bug causes a heap buffer overflow. If a user opens a file crafted to exploit this issue, it could lead to the program crashing, or overwriting of data and heap structures in ways not expected by the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
Title HTSlib CRAM reader has heap buffer overflow due to improper validation of input
Weaknesses CWE-122
CWE-129
CWE-787
References
Metrics cvssV4_0

{'score': 8.8, 'vector': 'CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:N/VC:N/VI:H/VA:L/SC:N/SI:N/SA:N'}

Sources

Status
PUBLISHED
Assigner
GitHub_M
Published
Updated
Mar 18, 2026, 6:52 PM
Reserved
Mar 10, 2026, 3:40 PM
Status
Analyzed
Published
Mar 18, 2026, 7:16 PM
Modified
Jun 17, 2026, 10:34 AM
Severity
Important
Public date
Mar 18, 2026, 6:22 PM