CVE-2026-54604

OpenSlide: openslide_read_region() returns uninitialized memory with libtiff 4.7.1

Published Sep 17, 2026 CVSS 4.0 · 5.3 Medium EPSS < 1% KEV · Not listed
Description
OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). A crafted but valid slide can trigger the issue in TIFF-based formats other than Hamamatsu NDPI when a network service renders attacker-provided slides. Successful extraction depends on pixel transparency handling and recompression, OpenSlide with libtiff 4.7.0 or earlier is not affected, and official binary builds 4.0.0.10 and 4.0.0.11 are affected. This issue is fixed in OpenSlide 4.0.1 and official binary build 4.0.0.12.

Remediation

No solution or workaround provided in the CVE record

Tracking

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Advisories

No advisories available
History
Type Values Removed Values Added
First Time appeared Openslide
Openslide openslide
Vendors & Products Openslide
Openslide openslide
Type Values Removed Values Added
Metrics ssvc

{'options': {'Automatable': 'no', 'Exploitation': 'none', 'Technical Impact': 'partial'}, 'version': '2.0.3'}

Type Values Removed Values Added
Description OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). A crafted but valid slide can trigger the issue in TIFF-based formats other than Hamamatsu NDPI when a network service renders attacker-provided slides. Successful extraction depends on pixel transparency handling and recompression, OpenSlide with libtiff 4.7.0 or earlier is not affected, and official binary builds 4.0.0.10 and 4.0.0.11 are affected. This issue is fixed in OpenSlide 4.0.1 and official binary build 4.0.0.12.
Title OpenSlide: openslide_read_region() returns uninitialized memory with libtiff 4.7.1
Weaknesses CWE-758
CWE-908
References
Metrics cvssV4_0

{'score': 5.3, 'vector': 'CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N'}

Weaknesses

Sources

Status
PUBLISHED
Assigner
GitHub_M
Published
Updated
Sep 18, 2026, 8:06 PM
Reserved
Jun 15, 2026, 7:45 PM
Status
Awaiting Analysis
Published
Sep 17, 2026, 9:17 PM
Modified
Sep 23, 2026, 6:12 PM