CVE-2026-31971

HTSlib CRAM decoder vulnerable to buffer overflow

Published Mar 18, 2026 CVSS 4.0 · 7.1 High EPSS < 1% KEV · Not listed
Description
HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. When reading data encoded using the `BYTE_ARRAY_LEN` method, the `cram_byte_array_len_decode()` failed to validate that the amount of data being unpacked matched the size of the output buffer where it was to be stored. Depending on the data series being read, this could result either in a heap or a stack overflow with attacker-controlled bytes. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.

Remediation

No solution or workaround provided in the CVE record

Tracking

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Advisories

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History
Type Values Removed Values Added
First Time appeared Htslib
Htslib htslib
CPEs cpe:2.3:a:htslib:htslib:*:*:*:*:*:*:*:*
cpe:2.3:a:htslib:htslib:1.23:*:*:*:*:*:*:*
Vendors & Products Htslib
Htslib htslib
Metrics cvssV3_1

{'score': 8.1, 'vector': 'CVSS:3.1/AV:N/AC:L/PR:N/UI:R/S:U/C:N/I:H/A:H'}

Type Values Removed Values Added
First Time appeared Samtools
Samtools htslib
Vendors & Products Samtools
Samtools htslib
Type Values Removed Values Added
Metrics ssvc

{'options': {'Automatable': 'no', 'Exploitation': 'none', 'Technical Impact': 'partial'}, 'version': '2.0.3'}

Type Values Removed Values Added
Description HTSlib is a library for reading and writing bioinformatics file formats. CRAM is a compressed format which stores DNA sequence alignment data using a variety of encodings and compression methods. When reading data encoded using the `BYTE_ARRAY_LEN` method, the `cram_byte_array_len_decode()` failed to validate that the amount of data being unpacked matched the size of the output buffer where it was to be stored. Depending on the data series being read, this could result either in a heap or a stack overflow with attacker-controlled bytes. Depending on the data stream this could result either in a heap buffer overflow or a stack overflow. If a user opens a file crafted to exploit this issue it could lead to the program crashing, overwriting of data structures on the heap or stack in ways not expected by the program, or changing the control flow of the program. It may be possible to use this to obtain arbitrary code execution. Versions 1.23.1, 1.22.2 and 1.21.1 include fixes for this issue. There is no workaround for this issue.
Title HTSlib CRAM decoder vulnerable to buffer overflow
Weaknesses CWE-121
CWE-122
CWE-1284
CWE-787
References
Metrics cvssV4_0

{'score': 7.1, 'vector': 'CVSS:4.0/AV:N/AC:L/AT:N/PR:N/UI:P/VC:N/VI:H/VA:L/SC:N/SI:N/SA:N'}

Sources

Status
PUBLISHED
Assigner
GitHub_M
Published
Updated
Mar 18, 2026, 8:15 PM
Reserved
Mar 10, 2026, 3:40 PM
Status
Analyzed
Published
Mar 18, 2026, 8:16 PM
Modified
Jun 17, 2026, 10:34 AM